Most family cancer syndromes are linked to pancreatic ductal adenocarcinoma , the most common type of pancreatic cancer. This causes lots of non-cancerous growths polyps in the digestive system, and dark spots on the hands and face. This condition mainly increases the risk of bowel and breast cancer, but may also increase the risk of pancreatic cancer. Faults in these genes greatly increase the risk of breast and ovarian cancer. They also increase the risk of other cancers, including prostate and skin cancer melanoma.
Genetics and Hereditary Factors of Pancreatic Cancer
Inherited Pancreatic Cancer Syndromes
A risk factor is anything that increases your chance of getting a disease such as cancer. Different cancers have different risk factors. Some risk factors, like smoking, can be changed. In some cases, there might be a factor that may decrease your risk of developing cancer or has an unclear effect. That is not considered a risk factor, but you may see them noted clearly on this page as well.
Hereditary pancreatic cancer: related syndromes and clinical perspective
Pancreatic cancer is a very aggressive disease with a poor prognosis. The majority of them are attributed to sporadic causes, especially to many modifiable risk factors such as tobacco or alcohol abuse. The principal histologic subtype of pancreatic cancer is ductal adenocarcinoma. Pancreatic neuroendocrine tumors, which constitute a more indolent entity, represent second type of pancreatic cancer in terms of incidence. Individuals with a family history of pancreatic cancer carry an increased risk of developing the disease, which may be related to an underlying hereditary component.
Pancreatic cancer remains one of the most challenging of all cancers. Genetic risk factors are believed to play a major role, but other than genes coding for blood group, genetic risks for sporadic cases remain elusive. However, several germline mutations have been identified that lead to hereditary pancreatic cancer, familial pancreatic cancer and increased risk for pancreatic cancer as part of a familial cancer syndrome.